Our medicine is produced and secreted in the gut using genetically engineered microbes.
Our approach in shaping the microbiome is to leave the beneficial microbes unharmed and promote a healthy intestinal environment.
Microbiome plays an important role in your health. Research shows that when microbial balance is disrupted, pathobionts take hold and can cause or promote a range of chronic diseases. Gutbiotics is focused on disorders where the causal link with microbes has been well established. These include:
Over 3 million Americans suffer from IBD which includes Crohn’s disease and Ulcerative colitis. IBD patients experience debilitating digestive symptoms like persistent diarrhea, rectal bleeding, and abdominal pain resulting in a detrimental impact on quality of life.
Over 12 million Americans suffering from irritable bowel syndrome (IBS) have an underlying condition of small intestinal bacterial overgrowth (SIBO)
Currently, there are no good options for precisely manipulating and fine tuning the microbiome.
have a broad-spectrum action and disrupt the entire microbiome by killing the beneficial bacteria. Antibiotics are the primary culprit behind gut dysbiosis.
The generally regarded as safe probiotic strains are gentle in action and good for intestinal health. However, they do not have the capability to decolonize pathogenic strains and shape the microbiome.
have a high specificity to the target bacterial strain. They require an accurate identification and isolation of the target bacteria for selecting appropriate phage.
Genetically engineered probiotics are a novel class of medicine and offer several advantages compared to traditional medicine.
Genetically engineered microbes can be programmed to secrete therapeutics for the same targets as top biologics. The microbes are administered through the simple oral route, thereby avoiding inconvenient doctors visits to receive biologics via IV.
Genetically engineered microbes have a local and targeted action in the gut. This avoids side effects and systemic immunosuppression.
Our narrow spectrum peptides selectively reduce pathogenic species of bacteria and leave the native microbiome intact. Further the engineered probiotic strains promote a healthy intestinal environment.
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Sumit Khetarpal2025-05-04 20:10:392025-05-04 22:09:31The Pathogens Behind Inflammatory Bowel Disease (IBD)
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Sumit Khetarpal2022-12-01 05:30:132023-07-26 05:01:46Pathogens Behind SIBO And Limitations of Rifaximin
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Sumit Khetarpal2022-09-21 13:01:162022-12-01 05:25:55Principal Scientist – Strain Engineering
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Sumit Khetarpal2022-01-10 03:14:402022-12-01 05:26:38A Tale Of Ineffective Antibiotics – Meet A SIBO Warrior Abigail Dancause